JACS 25位副主编的研究兴趣和实验室主页

JACS

所有

25

位副 主编列表：

/page/jacsat/

Eric

V.

Anslyn:

Supramolecular

Analytical

Chemistry,

small

molecule

therapeutics

/research/

Stephen J. Lippard:

bioinorganic chemistry. The core activities include both

structural and mechanistic studies of macromolecules as well as synthetic inorganic

chemistry.

The

focus

is

on

the

synthesis,

reactions,

physical

and

structural

properties of metal complexes as models for the active sites of metalloproteins and

as anti-cancer drugs. Also included is extensive structural and mechanistic work on

the

natural

systems

themselves.

A

program

in

metalloneurochemistry

is

also

in

place.

/lippardlab/

Weston Thatcher Borden:

Computational Chemistry; Organic Chemistry;

Organometallic Chemistry; Application of quantitative electronic structure

calculations and qualitative molecular orbital theory to the understanding and

prediction of the structures and reactivities of organic and organometallic

compounds.

/people-node/weston-t-borden

Thomas

E.

Mallouk:

Chemistry

of

Nanoscale

Inorganic

Materials:

Solar

Photochemistry

and

Photoelectrochemistry;

Nanowires;

Functional

Inorganic

Layered Materials; In-Situ Remediation of Contaminants in Soil and Groundwater

Using Nanoscale Reagents

/mallouk/

Benjamin F

. Cravatt:

Chemical Strategies for the Global Analysis of Enzyme

Function;

Technology

Development:

Activity-Based

Protein

Profiling

(ABPP);

Biological

applications

of

ABPP

-

profiling

enzyme

activities

in

human

cancer.;

Advancing

the

ABPP

technology;

Technology

Development:

Protease

Substrate

Identification; Basic Discovery: The Enzymatic Regulation of Chemical Signaling

/cravatt/

Chad A. Mirkin:

He is a chemist and a world renowned nanoscience expert, who

is

known

for

his

development

of

nanoparticle-based

biodetection

schemes,

the

invention

of

Dip-Pen

Nanolithography,

and

contributions

to

supramolecular

chemistry. Our research focuses on developing strategic and surface nano-optical

methods for controlling the architecture of molecules and materials on a 1-100 nm

scale.

Our

researchers,

with

backgrounds

ranging

from

medicine,

biology,

chemistry,

physics

and

material

science,

are

working

together

in

solving

fundamental and applied problems of modern nanoscience. Research in the Mirkin

laboratories is divided into the five areas listed below: Anisotropic Nanostructures;

On-Wire Lithography (OWL); Dip-Pen Nanolithography; Organometallic Chemistry;

Spherical Nucleic Acids

/mirkin-group/research/

Paul Cremer:

works

at

the

crossroads

of biological

interfaces,

metamaterials,

spectroscopy, and microfluidics. Biophysical and analytical studies are tied together

through

the

employment

of

novel

lab-on-a-chip

platforms

which

enable

high

throughput/low

sample

volume

analysis

to

be

performed

with

unprecedented

signal-to-noise. From neurodegenerative diseases to artificial hip implants, a huge

variety

of

processes

occur

at

biological

interfaces.

Our

laboratory

uses

a

wide

variety

of

surface

specific

spectroscopy

and

microfluidic

technologies

to

probe

mechanisms of disease, build new biosensors against pathogens, and understand

the molecular-level details of the water layer hugging a cell membrane. Research

projects in the Cremer Group are divided into the five areas listed below.

Click on

your

area(s)

of

interest

to

learn

more.

SFG

of

Water

and

Ions

at

Interfaces;

Hofmeister

Effects

in

Protein

Solutions;

Bioinorganic

Chemistry

and

Biomaterial

Properties

of

Lipid

Bilayers;

pH

Modulation

Sensing

at

Biomembranes;

Metamaterials

/cremer/

Jeffrey

S.

Moore:

Our

research

involves

the

synthesis

and

study

of

large

organic

molecules

and

the

discovery

of

new

polymeric

materials.

Most

projects

relate

to

one

of

three

areas:

new

macromolecular

architectures

and

their

supramolecular organization; responsive polymers including self-healing materials;

mechanochemical transduction. In general, our group uses the tools of synthetic

and physical organic chemistry to address problems at the interface of chemistry

and materials science. More in-depth information about our research can be found

on our research page.

/

Lyndon Emsley:

NMR

//Lyndon_Emsley/

Klaus Müllen:

The group pursues a broad program of experimental research in

macromolecular

chemistry

and

material

science.

It

has

a

wide

range

of

research

interests:

from

new

polymer-forming

reactions

including

methods

of

organometallic

chemistry,

multi-dimensional

polymers

with

complex

shape-persistent

architectures,

molecular

materials

with

liquid

crystalline

properties for electronic and optoelectronic devices to the chemistry and physics of

single molecules, nanocomposites or biosynthetic hybrids.

/groups/muellen

Jean

M.

J.

Fréchet:

Our

research

is

largely

concerned

with

functional

polymers,

from

fundamental

studies

to

applications.

The

research

is

highly

multidisciplinary

at

the

interface

of

several

fields

including

organic,

polymer,

biological, and materials chemistry. Chemical Engineering is also well represented

with our research in energy-related materials and microfluidics.

/

Eiichi Nakamura:

Fascination to learn about the nature of the elements and

molecules and to control their behavior goes back to ancient times. The research

programs

in

our

laboratories

focus

on

the

development

of

new

and

efficient

synthetic reactions, new reactive molecules, and new chemical principles that will

exert impact on the future of chemical, biological and material sciences. Under the

specific projects listed below, we seek for the new paradigm of chemical synthesis

and functional molecules. Discovery based on logical reasoning and imagination is

the key term of our research and educational programs.

/users/common/

Gregory C. Fu:

Transition Metal Catalysis; Nucleophilic Catalysis

/

William

R.

Roush:

Our

research

centers

around

themes

of

total

synthesis,

reaction

development

and

medicinal

chemistry.

Over

25

structurally

complex,

biologically active natural products have been synthesized in the Roush lab. These

serve

both

as

testing

grounds

for

new

methods

and

as

inspiration

for

potential

therapeutics.

Our total synthesis projects are often attempted in parallel with reaction design.

Synthetic

applications

of

intramolecular

Diels-Alder

reactions

and

acyclic

diastereoselective

syntheses

involving

allylmetal

compounds

are

of

especial

interest.

Total

synthesis

and

methods

development

interact

synergistically

toward

the

development

of

medicinally

relevant

compounds.

Current

targets

of

interest

include chemotherapeutics built upon the exploitation of tumor cell metabolism,

cystein

protease

inhibitors

for

treatment

of

parasitic

diseases

and

diagnostic

probes for the Scripps Molecular Screening Center.

/roush/

Miguel

Garcí

a-Garibay:

Our

group

is

currently

investigating

the

photochemical decarbonylation of crystalline ketones. Because the reactions take

place in the solid state, they exhibit high selectivites that are not possible by the

analogous

solution

reaction.

From

our

experience,

the

solution

photolysis

yields

many products, while there is often only one product in the solid. In order for the

decarbonylation reaction to proceed in crystals, there are a few requirements for