Charlson 合并症指数

J Chronic Dis.

1987;40(5):373-83.

A new method of classifying prognostic comorbidity in

longitudinal studies: development and validation.

Charlson ME

,

Pompei P

,

Ales KL

,

MacKenzie CR

.

Abstract

The objective of this study was to develop a prospectively

applicable method for classifying comorbid conditions which might

alter the risk of mortality for use in longitudinal studies. A weighted

index that takes into account the number and the seriousness of

comorbid disease was developed in a cohort of 559 medical

patients. The 1-yr mortality rates for the different scores were:

12% (181);

equal to 5

risk of death from comorbid disease in the second cohort of 685

patients during a 10-yr follow-up. The percent of patients who died

of comorbid disease for the different scores were:

25% (54);

With each increased level of the comorbidity index, there were

stepwise increases in the cumulative mortality attributable to

comorbid disease (log rank chi 2 = 165; p less than 0.0001). In this

longer follow-up, age was also a predictor of mortality (p less than

0.001). The new index performed similarly to a previous system