-
最全有机实验记录英文描述总结
一、加料过程常用表述
1.
添加试剂
2.
催化量的
3.
气体保护
4.
通入气体
5.
通过双针头导管加料
6.
通过注射器加料
二、反应过程常用表述
1.
反应检测
2.
放置过夜
3.
甲苯
/
乙醇带水
4.
氢化反应
5.
分水器
6.
反应放热
7.
微波反应
三、后处理过程常用表述
1.
过滤
2.
淬火
3.
磨碎
4.
在两相中分开
5.
静止固化
6.
在冻干机冻干
7.
纯化
过柱
制备
HPLC
纯化
制备
TLC
纯化
重结晶
8.
调
pH
9.
萃取
10.
浓缩
11.
干燥
干燥
真空干燥
四、部分常见反应现象描述
1.
加料放热
2.
反应过程中或者降温有固体析出
3.
加料不溶解
4.
加热溶解
5.
反应变粘稠
/
变色
五、特殊结果叙述
1.
无进一步处理
2.
统一和其他批次一起后处理
3.
检测条件，不需要后处理
六、一些易错写法
一、加料过程常用表述
1.
添加试剂
To a mixture (suspension / solution /
slurry) ofcompound
12
(487
mg, 1 mmol) and
o
-plenylenediamine (648 mg,
6 mmol) inCH
2
Cl
2<
/p>
(15 mL) being cooled to
0
o
C was
addedthe
DCC (226 mg, 1.1 mmol).
Anhydrous
lithium iodide (1.38 g, 10.3 mmol) was added the
five portions (dropwise/
in one portion
/ in portions) to a stirred solution of compound
12
(10.93 g, 51.5mmol)
in CH
2
Cl
2
(120 mL).
A round-bottom
flask was charged with compound
3
(1.75 g, 5.27 mmol), LiCl
(1.17
g, 26.3 mmol), DMSO (100 mL) and
H
2
O
(378
ul
)
2.
催化量的
Et
3
N (20 mL, 142
mmol) and a catalyticamount of DMAP were added the
solution of
compound
1
(4.549 g, 46.4mmol) in
CH
2
Cl
2
(120 mL) at 0
o
C
3.
气体保护
To a stirred
-
78
o
Cs
olution of trimethylsilyacetylene (4.44 g, 45.5
mmol) in THF (10
mL) under Argon
wasadded dropwise
n
-butylithium (1.6 M in
hexane, 28.25 mL).
4.
通入气体
An ozone-
enriched steam of oxygen was bubbled througha cold
(-78
o
C) solution of
compound
9
(128
mg, 1.409 mmol) in
CH
2
Cl
2
(5 mL) untilit turned light blue. The
solution was purged with argon at
-78
o
Cfor 10 min to remove
the excess O
3
.
5.
通过双针头导管加料
The mixture was added to a solution of
compound
2
(3.00 g, 12.8
mmol) in THF
(48mL) via cannula over a
period of 30 min.
A solution of
compound
29
(100 mg, 0.19
mmol, 1.0 equiv) in dry DMSO (1.5 mL)
wascannulated under Argon to a
vigorously stirred mixture of powered
potassiumsuperoxide (62 mg, 0.87 mmol,
4.5 equiv) and 18-crown-6-ether (23 mg,
0.087mmol, 0.45 equiv) in dry DMSO (0.5
mL).
6.
通过注射器加料
To a
stirred solution of compound
15
(8.61 g, 21.2 mmol)was
added a solution of
p
-toluenesulfonicacid (6.0
g) in CH
2
Cl
2
via syringe over 5 min.
二、反应过程常用表述
1.
反应检测
After 1 h,
TLC analysis (CH
2
Cl
2
/ hexane 3:1) showed the complete
consumption of
compound
15
.
2.
放置过夜
The mixture was left standing
overnight.
3.
甲
苯
/
乙醇带水
Compound
A
(1.97
g, 6.63 mmol) was coevaporatedwith toluene five
times to remove
the water.
The residue was subjected to toluene
azeotrope to givethe corresponding acid chloride
as brown oil.
The aqueous
portion was concentrated underreduced pressure
followed by azeotropic
removal of water
with absolute EtOH
4.
氢化反应
A mixture of
compound
1
(190 g, 0.88mmol)
and Raney Ni (20 g) inethanol (1500
mL)
and ethyl acetate (500 mL) was stirred under 1 atm
at room temperaturefor an
hour.
5.
分水器
A mixture of
TsOH.H
2
O (56.91 g, 0.3 mol)
and toluene (400 mL) washeated to reflux
to remove water by Dean-Stark trap.
6.
反应放热
The reaction
was exothermic.