章节的英文肿瘤信号通路图

PI3K / AKT

通路）

、

激素通路

（雌激素与雄激素通路）

，

< br>以及抗细胞增殖通路（

TGFβ

通路）。肿瘤的特征取决 于原发组织及遗传和环境因素。每种

肿瘤都是特定的信号通路组合的激活或失活所致。< /p>

对多重信号通路的分析可以快速了解决定

肿瘤生成的可能路径。< /p>

这张芯片不仅用于检测与特定肿瘤相关的信号通路，

而且可用于检 测

肿瘤类型。使用这一芯片试剂盒检测

RNA

< br>实验标本，操作者通过简便的杂交反应技术，即

可同时检测上述和肿瘤形成相关的 信号转导通路内标志物基因的表达水平变化。

Androgen Pathway:

CDK2, CDKN1A (p21Waf1/p21Cip1), EGFR, FOLH1, KLK2 (hGK2), KLK3 (PSA), TMEPAI.

Cox-2 Pathway:

FOS, HSPA4 (hsp70), MCL1, PPARG, PTGS2 (Cox-2), TNFRSF10B (DR5).

DNA Damage / p53 Pathways:

BAX, BCL2, CDKN1A (p21Waf1/p21Cip1), GADD45A (gadd45), HIF1A, HSPA4

(hsp70), IGFBP3, MDM2, PIG3, TNFRSF6 (Fas), TNFRSF10B (TrailR/DR5),

TRAF1, WIG1.

Estrogen Pathway:

BCL2, BRCA1, CTSD (cathepsin D), EGFR, PGR (PR), ZNF147 (Efp).

Hedgehog Pathway:

BMP2, BMP4, EN1 (engrailed), HHIP, FOXA2 (HNF3B), PTCH, PTCH2, WNT1,

WNT2, WSB1.

Hypoxia Pathway:

ADRA1B, CDKN1A, EDN1, EPO, HK1, HMOX1 (HO-1), IGFBP3, NOS2A (iNOS),

SLC2A1, TF, TFRC, VEGF.

Inflammation / NF-

κB Pathways:

ICAM1, IL2, LTA (TNFb), NF-

ΚB1 (NF

-

κB), NF

-

ΚBIA (IκBa), NOS2A (iNOS),

PECAM1, TNF (TNFa), VCAM1.

MAP Kinase Pathway:

COL1A1 (Collagen I), EGR1 (egr-1), FOS (c-fos), JUN (c-jun).

PI-3 Kinase / AKT Pathways:

BCL2, CCND1 (cyclin D1), FN1 (fibronectin), HIF1A, JUN (c-jun), MMP7

(matrilysin), MYC (c-myc), TNFSF10 (TRAIL)

STAT Pathway:

A2M (a2macroglobulin), BCL2, BCL2L1 (Bcl-XL), CSN2 (b

–

casein), CXCL9

(MIG), IL4, IL4R, IRF1, MMP10 (stromelysin-2), NOS2A (iNOS).

Stress / Heat Shock Pathways:

HSF1 (tcf5), HSPA4 (hsp70), HSPB1 (hsp27), HSPB2, HSPCA (hsp90)

Stress / p38 & JNK Pathways:

ABCB1 (Mdr1), ATF2, COL1A1 (Collagen I), DUSP1 (MKP1), ENPP2 (Autotaxin),

FOS, HSPA4 (hsp70), HSPA5 (Grp78), HSPB1 (hsp27), HSPB2, MYC, TP53.