狂犬病病毒简介及致病机理详解

及宿主细

胞对病毒感染应答方面等方面作一综 述。

关键词

：狂犬病

狂犬病毒

致病性

感染

Abstract

Rabies,

also

known

as

fear

of

water,

for

the

rabies

virus

caused

by

a

zoonotic

acute

infection

of

the

central

nervous

system.

More

common

in

dogs,

wolves,

cats

and

other

carnivores. Many people infected by the disease beast bites. Clinical manifestations of the unique

manic, fear of fear, fear of the wind fear of water, salivation and pharyngeal muscle cramps, and

finally paralyzed and endanger life as an ancient violation of the central nervous system, can cause

severe encephalomyelitis of violent human and animal infectious diseases, Once the disease, the

mortality rate is almost 100%.China is a high incidence of rabies countries, the number of rabies

cases

each

year

after

India,

ranking

second

in

the

world.

Rabies

is

caused by

a

rabies

virus,

in

which

RV

as

a

representative

species

is

the

main

cause

of

rabies.

In

recent

years,

with

the

development

of

molecular

biology

and

the

progress

of

research

methods,

people

have

a

deep

understanding of the structure and gene function of Rv, and accumulated rich data and theoretical

basis

for

the

development

and

transformation

of

rabies

vaccine.

In

this

paper,

we

reviewed

the

recent

advances

in

rabies

and

Rv,

and

reviewed

the

pathogenesis

of

Rv

and

host

cells,

such

as

glycoprotein, apoptosis, infection and immunity, replication and transcription, and the response to

virus infection.

Keywords:

Rabies

Rabies virus

Pathogenic

Infection

1

目

录

摘要

............................ .................................................. ..................................................

1

一、狂犬病病毒的介绍和分类

......................................... ....................................

3

二、狂犬病毒的特征和传染情况< /p>

........................................ .................................

4

（一）

传染源

......................... .................................................. .....................

5

（二）

传播途径

................................................ ............................................

5

（三）

传播对象

........................ .................................................. ..................

5

三、狂犬病病毒致病机理

........................ .................................................. ...........

6

（一） 糖蛋白

.................................... .................................................. ............

6

（二 ）细胞凋亡

.................................. .................................................. ..........

7

（三）感 染与免疫病毒的复制

.............................. ........................................

7

（四）复制和转录

.............................................. ............................................

8

参考文献

.................................................. .................................................. ....................

8

2

< /p>

狂犬病（

rabies

）又称恐水症（< /p>

hydrophobia

），为狂犬病病毒引起的一种人