英文论文投稿信Coverletter图文稿

qiusuo BY - 2006-1-17 8:59:00

Dear Editor,

We would like to submit the enclosed manuscript entitled

Acutely Modulates Neuronal Excitability and A-type Potassium

Channels in Midbrain Dopaminergic Neurons

considered for publication in Nature Neuroscience.

GDNF has long been thought to be a potent neurotrophic factor

for the survival of midbrain dopaminergic neurons, which are

degenerated in Parkinson’s disease. In this paper, we report

an unexpected, acute effect of GDNF on A-type potassium

channels, leading to a potentiation of neuronal excitability,

in the dopaminergic neurons in culture as well as in adult

brain slices. Further, we show that GDNF regulates the K+

channels through a mechanism that involves activation of MAP

kinase. Thus, this study has revealed, for the first time, an

acute modulation of ion channels by GDNF. Our findings

challenge the classic view of GDNF as a long-term survival

factor for midbrain dopaminergic neurons, and suggest that the

normal function of GDNF is to regulate neuronal excitability,

and consequently dopamine release. These results may also have

implicatio

ns in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we

request that Drs. XXX of Harvard Univ., and YY of Yale Univ.

not be considered as reviewers. With thanks for your

consideration, I am

Sincerely yours,

case2

Dear Editor,

We would like to submit the enclosed manuscript entitled

binding protein frequenin mediates GDNF-induced potentiation of

Ca2+ channels and transmitter release

considered for publication in Neuron.

We believe that two aspects of this manuscript will make it

interesting to general readers of Neuron. First, we report that

GDNF has a long-term regulatory effect on neurotransmitter

release at the neuromuscular synapses. This provides the first

physiological evidence for a role of this new family of

neurotrophic factors in functional synaptic transmission.

Second, we show that the GDNF effect is mediated by enhancing

the expression of the Ca2+-binding protein frequenin. Further,

GDNF and frequenin facilitate synaptic transmission by

enhancing Ca2+ channel activity, leading to an enhancement of

Ca2+ influx. Thus, this study has identified, for the first

time, a molecular target that mediates the long-term, synaptic

action of a neurotrophic factor. Our findings may also have

general implications in the cell biology of neurotransmitter

release.

[0630][

投稿写作

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某杂志给出的标准

Sample Cover Letter[the example

used is the IJEB]

Case 3

Sample Cover Letter[the example used is the IJEB]

Dear Editor of the [please type in journal title or acronym]:

Enclosed is a paper, entitled

Management.

the [journal title]. Below are our responses to your submission

requirements.

1. Title and the central theme of the article.

Paper title:

reviews the concepts of mobile agents and distributed network

management system. It proposes a mobile agent-based

implementation framework and creates a prototype system to

demonstrate the superior performance of a mobile agent-based

network over the conventional client- server architecture in a

large network environment.

2. Which subject/theme of the Journal the material fits

New enabling technologies (if no matching subject/theme, enter

'Subject highly related to [subject of journal] but not listed

by [please type in journal title or acronym])

3. Why the material is important in its field and why the

material should be published in [please type in journal title

or acronym]

The necessity of having an effective computer network is

rapidly growing alongside the implementation of information

technology. Finding an appropriate network management system

has become increasingly important today's distributed

environment. However, the conventional centralized architecture,

which routinely requests the status information of local units

by the central server, is not sufficient to manage the growing

requests. Recently, a new framework that uses mobile

agent technology to assist the distributed management has

emerged. The mobile agent reduces network traffic, distributes

management tasks, and improves operational performance. Given

today's bandwidth demand over the Internet, it is important for

the [journal title/acronym] readers

to understand this technology and its benefits. This study

gives a real-life example of how to use mobile agents for

distributed network management. It is the first in the

literature that reports the analysis of network performance

based on an operational prototype of mobile agent-based

distributed

network. We strongly believe the contribution of this study

warrants its publication in the [journal title/acronym].

4. Names, addresses, and email addresses of four expert

referees.

Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall

Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail:

Expertise: published a related paper (

Strategies for Interconnection

Relationship: I met Dr. Gate only once at a conference in 1999.

I didn't know him personally.

Assoc Prof. Dr. John Adams

Director of Network Research Center

College of Business Australian University

123, Harbor Drive Sydney,

Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886

e-mail:

Expertise: published a related paper (

in IEEE TOSE, 18(8), pp. 88-98.

Relationship: None. I have never met Dr. Adams.

Assoc Prof. Dr. Chia-Ho Chen

Chair of MIS Department

College of Management

Open University

888, Putong Road

Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886

e-mail:

Expertise: published a related paper (

E-Commerce

Relationship: Former professor, dissertation chairman.

Mr. Frank Young

Partner, ABC Consulting

888, Seashore Highway

Won Kok, Kowloon

Hong Kong

phone: +852-8888-8888 - fax: +852-8888-8886