投稿coverletter写法

Case 1

Dear Editor,

We would like to submit the enclosed manuscript entitled

Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons

to be considered for publication in Nature Neuroscience.

GDNF

has

long

been

thought

to

be

a

potent

neurotrophic

factor

for

the

survival

of

midbrain

dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an

unexpected,

acute

effect

of

GDNF

on

A-type

potassium

channels,

leading

to

a

potentiation

of

neuronal

excitability,

in

the

dopaminergic

neurons

in

culture

as

well

as

in

adult

brain

slices.

Further,

we

show

that

GDNF

regulates

the

K+

channels

through

a

mechanism

that

involves

activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of

ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival

factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to

regulate neuronal excitability, and consequently dopamine release. These results may also have

implications in the treatment of Parkinson’s disease.

Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ.,

and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am

Sincerely yours,

case2

Dear Editor,

We

would

like

to

submit

the

enclosed

manuscript

entitled

protein

frequenin

mediates GDNF- induced potentiation of Ca2+ channels and transmitter release

to be considered for publication in Neuron.

We

believe

that

two

aspects

of

this

manuscript

will

make

it

interesting

to

general

readers

of

Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release

at

the

neuromuscular

synapses.

This

provides

the

first

physiological

evidence

for a

role

of

this

new family of neurotrophic factors in functional synaptic transmission. Second, we show that the

GDNF

effect

is

mediated

by

enhancing

the

expression

of

the

Ca2+-binding

protein

frequenin.

Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity,

leading

to

an

enhancement

of

Ca2+

influx.

Thus,

this

study

has

identified,

for

the first

time,

a

molecular

target

that

mediates

the

long-term,

synaptic

action

of

a

neurotrophic

factor.

Our

findings may also have general implications in the cell biology of neurotransmitter release.

某杂志给出的标准

Sample Cover Letter

Case 3

Sample Cover Letter

Dear Editor of the :

Enclosed

is

a

paper,

entitled

Agents

for

Network

Management.

Please

accept

it

as

a

candidate for publication in the . Below are our responses to your submission requirements.

1. Title and the central theme of the article.

Paper

title:

Agents

for

Network

Management.

This

study

reviews

the

concepts

of

mobile agents and distributed network management system. It proposes a mobile agent- based

implementation

framework

and

creates

a

prototype

system

to

demonstrate

the

superior

performance of a mobile agent-based network over the conventional client-server architecture in

a large network environment.

2. Which subject/theme of the Journal the material fits

New enabling

technologies (if

no

matching

subject/theme, enter

'Subject

highly

related

to

but

not listed by )

3. Why the material is important in its field and why the material should be published in ?

The

necessity

of

having

an

effective

computer

network

is

rapidly

growing

alongside

the

implementation of information technology. Finding an appropriate network management system

has become increasingly important today's distributed environment. However, the conventional

centralized

architecture,

which

routinely

requests

the

status

information

of

local

units

by

the

central server, is not sufficient to manage the growing requests. Recently, a new framework that

uses mobile

agent technology to assist the distributed management has emerged. The mobile agent reduces

network

traffic,

distributes

management

tasks,

and

improves

operational

performance.

Given

today's bandwidth demand over the Internet, it is important for the readers

to understand this technology and its benefits. This study gives a real-life example of how to use

mobile agents for distributed network management. It is the first in the literature that reports the

analysis

of

network

performance

based

on

an

operational

prototype

of

mobile

agent- based

distributed

network. We strongly believe the contribution of this study warrants its publication in the .

4. Names, addresses, and email addresses of four expert referees.

Prof. Dr. William Gates

Chair Professor of Information Technology

321 Johnson Hall

Premier University Lancaster, NY 00012-6666, USA

phone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail:

wgates@

Expertise:

published

a

related

paper

(

and

OSI:

Four

Strategies

for

Interconnection

in

CACM, 38(3), pp. 188-198.

Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.

Assoc Prof. Dr. John Adams

Director of Network Research Center

College of Business Australian University

123, Harbor Drive Sydney,

Australia 56789

phone: +61-8-8888-8888 - fax: +61-8-8888-8886

e-mail:

jadams@

Expertise: published a related paper (

Relationship: None. I have never met Dr. Adams.

Assoc Prof. Dr. Chia-Ho Chen

Chair of MIS Department

College of Management

Open University

888, Putong Road

Keelung, Taiwan 100

phone: +886-2-8888-8888 - fax: +886-2-8888-8886

e-mail:

chchen@