-
promotion of empl
oyment, form a
rea
sonable a
nd
orderly
pattern of
i
ncome
distri
buti
on,
bui
ld a more fair
a
nd sustai
nable
social se
curity
systems, medi
cal and health
system reform. T
he
pl
enar
y,
innovati
on of soci
al
governance, must focus on the
mainte
nance
of
fundame
ntal interest
s of the
overwhelming majority of the
pe
ople, maximize
fact
ors, e
nha
nce
social development,
impr
oving soci
al governance,
the i
nterests
of national
se
curit
y, e
nsure
t
hat the
people live
a
nd w
ork, soci
al
stabil
ity and
orde
r.
o improve
social gover
nance,
stimulati
ng social
organizati
on,
i
nnovative and effective system of
preventing
and resolvi
ng
social
conflicts, impr
oving
t
he publi
c
se
curity system,
set up the
National Security Council
,
national security systems and
nati
onal
se
curity
strategy to e
nsur
e national
security.
Plenary
sessi
on, the
construction of ecologi
cal
civ
ilization, you must
esta
bli
sh systems
of ecol
ogical system, using
the system to
protect t
he
ecologi
cal
e
nvironme
nt.
o
improve natural
resour
ces
asset property right system a
nd use
control, red li
ne of delimitation of
e
col
ogical
protecti
on,
re
sources
paid
use system a
nd
e
col
ogical
compensati
on
sy
stem in ecologi
cal
envir
onme
nt
prote
ction management sy
stem
reform. Plenary
sessi
on,
ce
ntering on building a
liste
ning party comma
nd, can
wi
n and havi
ng a fine style
of the pe
ople'
s army, a
strong army under the
new
sit
uation of the
party
Goal
s, restricti
ng the
development of
nati
ona
l defense and army
buil
ding i
s
solve
d outstanding
contra
dicti
ons
a
nd
problems,
i
nnovati
on a
nd
develo
pment of military
the
ory, enhance milit
ary
strategic guida
nce, improve
t
he military strategy in the
new
period, building a
modern m
ilitary force system with
Chi
nese
chara
cteristics.
o dee
pen t
he
adjustment of
personnel system reform
in the army, military
poli
cy
and system reform, prom
ote the
development of military and civi
lian
integration de
pth.
Plenary
session
stresse
d that
com
pre
hensive reform must be
to
strengthen a
nd
impr
ove the
party's
leader
shi
p, give full play
to the core r
ole of the
party commands t
he overall
sit
uation and coordi
nating
all parties, impr
oving the
party's leadi
ng water ...
Margin.
Challe
nged t
he
leadershi
p of the Communi
st
Party of Chi
na, Marxi
sm-
Leni
nism and Mao Ze
dong
thought by
Deng
Xiao
-pi
ng's
fla
g, replace
d by
thre
e representatives and the
harmonic societ
y.
The former Communist Party spirit and
social cohesi
on
poi
nt of almost all
politica
l makeover.
Chara
cteristics
of socialism publi
c
ow
nership is
shifting to
private ow
nership,
planned reg
ulation and
market regulati
on, t
he
pr
oletari
an regime
controlle
d by the elite. Of
univ
ersal equality, fairness
a
nd
basi
c
principl
es of
distri
buti
on
sy
stem is socialist societ
y,
however after economic monopolize
d by
powerful, ve
sted interest
s
grow
employers
do
not have t
he same status,
har
dly se
ems fair
socia
l
distri
buti
on.
State key protection
of
capital i
nterests rather
tha
n the i
nterests of
citizens, had
bee
n hits the
bott
om of the prol
etariat
细胞色素
p450
酶的部分资料
P450
的检测意义
解释药效个体差异
解释毒性反应
用药个体化的理论基础
预测和防治治疗过程中出现的药物相互作用
P450
酶的体内分布
主要位于肝脏
也见于肠道、肾脏和脑内
P450
酶功能
催化内源物质
(
如甾类化合物
)<
/p>
的代谢
催化外源物质
< br>(
如药物
)
的代谢
（结果对机体可能有益也可能有害）
P450
酶功能与药物的关系
P450
酶的功能涉及到体内药物的氧化代谢、生物活化和细胞毒性致
活
氧化代谢途径包括羟化、去甲基、去烷基和环氧化等
P450
酶的相关信息
药理作用
肝脏的细胞色素
P450
系统在药物的代谢中起着重要作用，它将药物由疏水型转
化为更易排泄的亲
水型。
生物转化反应一般可分为细胞色素
P450
依赖的
I
相和
II
相
结合反应。最近几年内已清楚药物的肝外代谢对体内药物总的降解起一
定的作用。胃
肠道内的生物转化是非常重要的，
因为它可降低口
服药物的生物利用度。
遗传多态性、
酶抑制、酶诱导及生理因素
均可引起细胞色素
P450
活性的改变。这有一定的临床含
意，因为这会引起药物药代动力学的改变，导致药物效能改变，因代谢减少或毒性代
谢物生成增多而增加药物毒性，以及导致药物的相互作用。
细胞色素
P450
< br>同工酶是血红蛋白超级家族，
它是内质网膜上混合功能氧化酶系统的末端氧
化酶。称呼这些为同工酶是由于其与一氧化碳结合和还原时，分光光度法测得的吸收峰在
450nm
附近。
P450
< br>同工酶认为已存在了
350
万年，在细菌、真菌及动植物
中均可发现其
存在。现在已清楚认为人类细胞色素酶参与外源性物质（如药物、酒精、抗
氧化剂、有机溶
剂、麻醉药、染料、环境污染物质、化学制品）的代谢，所产生的代谢产
物可能有毒性或致
癌性。
它们在氧化、
过氧化和还原内源性生理化合物，
如甾体、
胆汁酸、
脂肪酸、
前列腺素、
生物源性氨类和
retinoids
等代谢起重要作用。
最近除了研
究细胞色素同工酶参与代谢以外，
还揭示了其新的生理及病理作用。
细胞色素
P450
酶是肝脏内的一个重要酶系，
75%
的药物都由它
来进行代谢。
包括外源性和
内源性的药物代谢，既有
I
相代谢，及氧化，或脱氢等；也有
II
相代谢，如磺酸化等。。
bvi
ousl
y, face
Chi
na's Socialist
sy
stem, the Communi
st Party
is not the
party.
In that
case,
politi
cal
chaos ha
s bee
n very tight.
Is remodeling
or
reconstr
ucti
on,
i
s a correction or a
stove.
Whet
her to tur
n
right
or left, is ba
ck to
the source
or put
forward
new political i
deas.
This is to determine the
r
oad pr
obl
ems in
China, is al
so the key out
of the de
ep water
of the reform of the
e
conomic sy
stem.
After 18, the new Ce
ntral
coll
ective lea
dership
attaches great importance to
politi
cal
orie
ntation.
First, the
cles
ng point,
starti
ng from the Ce
ntral
Governme
nt's
self
-re
straint,
whi
ch
prea
ches
a
nd
pro-image,
br
oug
ht fresh feeling to
t
he communit
y.
Secondly,
before reform and
openi
ng up and reform and
openi
ng two
periods after
non-negative,
untyi
ng the
tangl
e of the soci
ety a long
time on t
his issue. Third, a
ne
w generation of part
y
leaders on various
occasions to
Mao Ze
-Dong a
nd
Ma
o Ze
-Dong's
thoug
ht of evaluati
on has
room for manoe
uvre,
throug
h to the
r
uling i
deol
ogy
of Ma
o Zedong thought, i
s
the
call of the soul t
o the
S
ocialist Revol
ution and
constr
ucti
on. Empty talks
jeopardize
national
interest
s and try again, is
a
n affirmation of De
ng
Xia
o-ping's reform i
deas.
These strong politica
l
signal
showing a
new
ge
neration
of
poli
tical leader
s is still
kee
ping to t
he Socialist
roa
d.
Four is revisiting
t
he
o Ze-Dong's
hi
storical
cycle
of
ofile
anti
-corrupti
on
a
nd t
he
importa
nce
of the
Constit
ution, reorga
nization
is ba
d style of official
dom,
wa
s to civ
ilize people obey
the la
w
, w
hile
impr
oving the col
or change
of the regime of vigila
nce.
Five is to reform into
dee
per waters a
nd stressed
t
hat top
-level
design, this i
s a review on
the reform and openi
ng up in
t
he past, i
s also
look
ing for a way o
ut.
Six foreign and Russia
cl
oser, the flexibl
e
attitude
on the issue of the
Korea
n
pe
ninsula
,
Sino
-Japane
se
fishi
ng har
dli
ne
China
on the island out of the
nt
ow pr
ofile
sha
dow bega
n to
gradua
lly pla
n
development. Signs show that
t
he new l
eadership
began t
o make a left turn in
politics.
However, as of right now, not
only ide
ologi
cal
confusi
on i
n the
community, the new
lea
dership's
t
hinki
ng is messy.
Ne
w leader
s bot
h
stresse
d the
need
t
o implement t
he
Constituti
on, stresse
d the
need t
o turn off the
power
i
n a cage. Al
so
stre
sses that Mao Zedong
t
hought ca
nnot be lost, 30
years after the reform and openi
ng up
30 years ago
can
not deny
each ot
her.
Bot
h
advocate dem
ocracy a
nd
rele
ase
n does not speak
of
cal
constraint
s. Neit
her
de
ny the
history of the
CPC Central Committee on several issues
...
Comrades: today
brings
t
ogether member
s, mainly in
order to
provi
de
a platform to Exchange a
nd
lear
n from each
other
i
n order t
o facilitate our
work. Just now, we focus
on taxation,
pla
nni
ng and
stabilit
y, safety,
proje
ct
constr
uction, typi
cal topics
such as
private facts
prese
ntation and
interacti
on, and
towns
currently exist in the in-de
pth
a
nalysis
of the problems to
be solved, to ex
plore
new methods t
o solve
t
he pr
oblem. It
can
be sai
d that
summing
up t
he achievement,
no grandstanding
;
analy
sis
-
-
-
-
-
-
-
-
-
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