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TNF
信号通路图
日期：
2012-04-16
来源：未知
标签：
肿瘤坏死因子
信号
TNF
acts
several
通路
摘要
:
TNF
信号通路图
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TNF acts on several
different signaling pathways through two cell
surface receptors,
TNFR1 and TNFR2 (See
TNFR1 and TNFR2 Signaling Pathways) to regulate
apoptotic
pathways, NF-kB activation of
inflammation, and activate stress-activated
protein kinases
(SAPKs). Interaction of
TNFR1 with TRADD leads to activation of NF-kB and
apoptosis
pathways, while interaction
with TRAF2 has
GENE
rally
been thought to be involved in
stress
kinase and NF-kB activation but is not required
for TNF to induce apoptosis.
Activation
of NF-kB is mediated by TRAF2 through the NIK
kinase and also by RIP but the
observation that TNF activates NF-kB in
mice lacking TRAF2 indicates that TRAF-2 does
not play an essential role in this
process. Stress-activated protein kinases, also
called