-
有机实验操作英语表达
--
后处理过程中常用的
表述
过滤
The mixture was
filtered through a Celite pad, and the filtrate
was concentrated to
give crude product.
淬灭
The reaction mixture was
quenched by the addition of saturated aqueous
NH4Cl.
An aqueous solution of A (0.5 M,
10 mL) was added dropwise into the reaction
mixture once the
reaction mixture
(solution or suspension) was warmed (or cooled) to
-5
℃
or room
temperature
(ambient temperature).
The hot (or cold) reaction mixture
(solution or suspension) was poured into water
(ice water) or
poured onto ice.
The
reaction
mixture
(solution
or
suspension)
was
concentrated
(distilled)
under
reduced
pressure (in vacuum)
or evaporated to remove MeOH (THF; DMF etc.) or
excess SOCl2 (reagent).
The
residue
(or
the
residual)
was
diluted
with
solvent
and
poured
into
water
(ice
water)
or
poured onto ice.
分液
After quenching the reaction, the
reaction mixture was poured into separatory funnel
and separated.
磨碎
The residue was triturated with ether
and filtered to afford a white solid.
在
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中两相分开，隔开
The residue was partitioned
between EtOAc (100 mL) and 1 N aq. HCl (50 mL).
The organic layer
was washed with H2O,
dried (MgSO4) and evaporated to dryness.
EtOAc
(100
mL)
and
1
N
aq.
HCl
(50
mL)
were
added
to
the
residue,
and
the
layers
were
separated.
静止固化
The crude product was purified by prep.
HPLC to give compound 4 as a colorless
thick oil which was solidified on
standing.
冻干机冻干
The white solid
(105249x43A) was re-crystallized from water, dried
by hyophilization
to give WP-100418
(105249x43B, 45.0 g, 39.2%) as a white solid.
纯化
过柱：
The crude product was chromatographed
on silica gel (acetone/dichloromethane 10:90
→
10:80
→
10:70
) to give compound 8 (0.282 g, 51%) as a white
solid.
The
crude
product
was
purified
by
column
chromatography
on
silica
gel
eluted
with