两次p53信号通路

p53 Signaling

RT? Profiler? PCR Array

p53 Signaling Pathway PCR Array

Cellular Senescence PCR Array

DNA Damage Signaling Pathway PCR Array

Cell Cycle PCR Array

SureSilencing RNAi

p53 Signaling Pathway Gene RNAi

Cellular Senescence Gene RNAi

DNA Damage Signaling Pathway Gene RNAi

Cell Cycle Gene RNAi

Cignal? Reporter Assays

p53 Pathway Reporter Assay Kit

E2F Reporter Assay Kit

EGR1 Reporter Kit

p53 is a tumour suppressor protein that regulates the expression of a wide variety of genes involved in Apoptosis, Growth arrest,

Inhibition of cell cycle progression, Differentiation and accelerated DNA repair or Senescence in response to Genotoxic or

Cellular Stress. As a transcription factor, p53 is compos

ed of an N-terminal Activation Domain, a central specific DNA Binding

Domain, and a C-terminal Tetramerization Domain, followed by a Regulatory Domain rich in basic Amino acids. Having a short

half-life, p53 is normally maintained at low levels in unstress

ed mammalian cells by continuous ubiquitylation and subsequent