电话销售教程雷洛昔芬与结合雌激素联合应用对去势大鼠血栓前状态的影响

2021年1月5日发(作者：曾南)
雷洛昔芬与结合雌激素联合应用对去势大鼠血栓前状态的
影响
高辉;奚水;徐苓


【期刊名称】《中华妇产科杂志》

【年(卷),期】2013(048)012

【摘要】Objective To study effects of raloxifene (RLX) with different
doses of conjugated equine estrogen(CEE) on prothrombotic profiles in
the ovariectomized rats s Total of 32healthy female SD
rats at age of 9 to 10 months were equally divided into every 8 rats at 4
groups week after ovariectomized,they were treated by
drugs,including control group with placebo(0.9％ Nacl intragastric
administration),RLX group with RLX 6 mg(kg · d),RLX and low CEE
group with RLX 6 mg(kg · d) + CEE 0.07 mg(kg · d)and RLX and high
CEE group with RLX 6 mg(kg · d) + CEE 0.5mg(kg· d)for 10 weeks
before in turbidimetry method was used to evaluate the
plasma fibrinogen(FIB),transmitting substrate method for antithrombin
Ⅲ (AT Ⅲ) activity,double-antibody sandwich ELISA for plasminogen
activator inhibitor 1 (PAI-1),D-dimer (D-D) and yon Willebrand factor
(vWF) and nitrate reductase method for nitric oxide(NO).Results (1)
Coagulation and anticoagulation indicators:it was observed (1.62 ± 0.22)
gL FIB at control group,(2.02 0.54) gL at RLX group,(1.97 ±0.16) gL at
RLX and low CEE group,(2.00 0.18) gL at RLX and high CEE