节日短信大全茶叶中EGCG对非酒精性脂肪肝大鼠的调脂保肝作用研究

2020年12月31日发(作者：闻良波)

茶叶中EGCG对非酒精性脂肪肝大鼠的调脂保肝作用研究
严煜钧;刘仲华;林勇; 黄建安;彭彬;蒋华军


【期刊名称】《茶叶科学》

【年(卷),期】2014(000)003

【摘要】Non-alcoholic fatty liver disease (NAFLD) is a pathological
metabolic syndrome performed as the fat accumulation andor fatty
degeneration in the liver, which is directly re levant to lipid metabolic
disorder. In order to investigate the effects of EGCG from tea on
regulating lipid metabolism and alleviating liver injury in rats with
NAFLD, NAFLD model rats were established by feeding a high fat diet,
and then the rats of EGCG protective groups were given daily oral
administration of EGCG with three doses of 10, 50 mg·kg-1 and 100
mg·kg-1, respectively. The results showed that, compared with the
model group, EGCG could decrease serum levels of triglyceride (TG),
total cholesterol (TC) and low density lipoprotein- cholesterol (LDL-C),
increase serum level of high density lipoprotein-cholesterol (HDL-C),
reduce activities of alanine aminotransferase (ALT) and aspartate
aminotransferase (AST) in the serum, and ameliorate liver oxidative
stress. Also, histological analysis showed that EGCG could reduce the
formation of lipid droplets in the liver cells, and RT-PCR analysis showed
that EGCG could regulate the expression of genes involved in lipid
metabolism. Taken together, these experiment results indicated that